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Alley claimed she had been a compulsive eater her entire life without gaining weight, and only noticed a change in her body after she went through early menopause in 1992.
In 2012, she faced a class-action lawsuit alleging false advertising; the suit claimed that her weight loss was the result of exercise, including training for the TV show Dancing With the Stars, not Organic Liaison products.
In 2005, she played a fictionalized version of herself on Showtime's Fat Actress.
She later appeared on the reality show Kirstie Alley's Big Life (2010), and was a contestant on the twelfth season of Dancing with the Stars (2011–12), finishing in second place.
In 1987, Alley starred alongside Mark Harmon in the comedy film Summer School.
The film was a box office success, grossing over million in the United States.
Alley finished the competition in second place, behind NFL Super Bowl champion Hines Ward.Alley received a star on the Hollywood Walk of Fame in 1995.Alley has appeared in several movies, including Summer School (1987), Shoot to Kill (1988), Look Who's Talking (1989) and its two sequels (1990–93), Madhouse, Sibling Rivalry (both 1990), Village of the Damned, It Takes Two (both 1995), Deconstructing Harry, For Richer or Poorer (both 1997), and Drop Dead Gorgeous (1999).For her contributions to the film industry, Alley received a motion pictures star on the Hollywood Walk of Fame at 7000 Hollywood Boulevard in 1995.From 1997 to 2000, Alley played the title character in the NBC sitcom Veronica's Closet, as well as serving as executive producers on the show.